NAD+ 500 to 1000 mg
Cellular coenzyme, not a peptide · almost all the good human evidence is from oral precursors, not injected NAD+
NAD+ (nicotinamide adenine dinucleotide) is not a peptide: it is a coenzyme, a small molecule made of two nucleotides joined by their phosphates, that almost every cell in the body uses constantly. On one hand it carries electrons in the reactions that generate energy (glycolysis, the Krebs cycle, the respiratory chain); on the other, it is consumed as raw material by enzymes that repair DNA, regulate genes and control the immune system, such as sirtuins, PARPs and CD38. Its levels fall with age in several species, including humans, and that drop is linked to loss of metabolic function (citations 1 and 2). Almost all the good clinical evidence in humans — randomized, placebo-controlled trials with a decent number of patients — comes from the two precursors taken by mouth, nicotinamide riboside and nicotinamide mononucleotide, not from injected NAD+ (citations 4 and 5). The likely reason is that NAD+ is a large, charged molecule that does not easily cross an intact cell membrane: enzymes on the outer surface of the cell, especially CD38, cut it into smaller pieces (nicotinamide, ADP-ribose) before those pieces can enter, and it is inside the cell that NAD+ gets rebuilt (citations 3, 6 and 7). So raising NAD+ in the blood with an infusion does not guarantee raising it inside the tissue.
CAS: 53-84-9. Lyophilized powder: -20 °C, stable.
Articles
- NAD+ 500 mg: $105
- NAD+ 1000 mg: $145
For research use only. Not for human consumption.